p27 – MMab

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Ihc Of P27 On An Ffpe Breast Adenocarcinoma Tissue

IHC of p27 on an FFPE Breast Adenocarcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanationp27KIP1 is a cell cycle regulatory mitotic inhibitor of Cdk activity. p27KIP1 is a candidate-tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Low p27 expression has been associated with unfavorable prognosis in Renal-cell Carcinoma,Colon Carcinoma, Small Breast Carcinomas, Non-small-cell Lung Carcinoma, Hepatocellular Carcinoma, Multiple Myeloma, lymph node metastases in Papillary Carcinoma of the Thyroid, and a more aggressive phenotype of Carcinoma in the Cervix.
Antibody TypeMouse MonoclonalCloneSX53G8
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationNuclearControlProstate, Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma
PresentationAnti-p27 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5834PredilutedReady-To-Use3.0 ml
BSB 5835PredilutedReady-To-Use7.0 ml
BSB 5836PredilutedReady-To-Use15.0 ml
BSB 5837Concentrated1:25-1:1000.1 ml
BSB 5838Concentrated1:25-1:1000.5 ml
BSB 5839Concentrated1:25-1:1001.0 ml
BSB 5840Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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