Products

Chromogranin A – MMab

IHC of Chromogranin A on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory pro-teins. Examples of cells producing chromogranin A are the adrenal medulla, enterochromaffin-like cells and beta cells of the pancreas. The function of chromogranin A is unknown but it is a precursor to 3 functional peptides: vasostatin, pancreastatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A is an excellent marker for Carcinoid Tumors, Pheochromocytomas, Paragangliomas, and other Neuroendocrine Tumors. Coexpression of chromogranin A and neuron-specific enolase (NSE) is common in neuroendocrine neoplasms. It has been identified in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine and parathyroid. It is generally accepted that the coexpression of certain keratins and chromogranin means neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. Most pituitary adenomas and prolactinomas readily express chromogranin.
Antibody Type Mouse Monoclonal Clone LK2H10
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Pancreas, Pituitary, Colon, Brain
Presentation Chromogranin A is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5344 Prediluted Ready-To-Use 3.0 ml
BSB 5345 Prediluted Ready-To-Use 7.0 ml
BSB 5346 Prediluted Ready-To-Use 15.0 ml
BSB 5347 Concentrated 1:250-1:1000 0.1 ml
BSB 5348 Concentrated 1:250-1:1000 0.5 ml
BSB 5349 Concentrated 1:250-1:1000 1.0 ml
BSB 5350 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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