Chromogranin A – MMab

Chromogranin A Mmab

IHC of Chromogranin A on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationChromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory pro-teins. Examples of cells producing chromogranin A are the adrenal medulla, enterochromaffin-like cells and beta cells of the pancreas. The function of chromogranin A is unknown but it is a precursor to 3 functional peptides: vasostatin, pancreastatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A is an excellent marker for Carcinoid Tumors, Pheochromocytomas, Paragangliomas, and other Neuroendocrine Tumors. Coexpression of chromogranin A and neuron-specific enolase (NSE) is common in neuroendocrine neoplasms. It has been identified in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine and parathyroid. It is generally accepted that the coexpression of certain keratins and chromogranin means neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. Most pituitary adenomas and prolactinomas readily express chromogranin.
Antibody TypeMouse MonoclonalCloneLK2H10
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlPancreas, Pituitary, Colon, Brain
PresentationChromogranin A is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5344PredilutedReady-To-Use3.0 ml
BSB 5345PredilutedReady-To-Use7.0 ml
BSB 5346PredilutedReady-To-Use15.0 ml
BSB 5347Concentrated1:250-1:10000.1 ml
BSB 5348Concentrated1:250-1:10000.5 ml
BSB 5349Concentrated1:250-1:10001.0 ml
BSB 5350Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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