Alpha-1-Antichymotrypsin – Rabbit Polyclonal

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IHC of Alpha-1-Antichymotrypsin on a FFPE Tonsil Tissue

United States
Research Use
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationAlpha-1-Antichymotrypsin Glycoprotein found in alpha (1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily. Alpha-1-Antichymotrypsin antibody reacts with histiocytes and histiocytic neoplasms. Its major application is defining the presence of Alpha-1-Antichymotrypsin in histiocytes and tumors derived from them. In eosinophilic granuloma and malignant histiocytosis, the reaction for this marker is heterogeneous in intensity and distribution. In fibrous histiocytomas, under certain circumstances, a diffuse homogeneous reaction may be observed.
Antibody TypeRabbit PolyclonalCloneN/A
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlTonsil, Lymph Node
PresentationA-1-Antichymotrypsin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Special NoteConcentrated A-1-Antichymotrypsin antibody should be diluted to its working dilution in ImmunoDNA Background Blocker (Cat.# BSB 0103, BSB 0104, BSB 0105, BSB 0106 or BSB 0107)
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5001PredilutedReady-To-Use3.0 ml
BSB 5002PredilutedReady-To-Use7.0 ml
BSB 5003PredilutedReady-To-Use15.0 ml
BSB 5004Concentrated1:250-1:10000.1 ml
BSB 5005Concentrated1:250-1:10000.5 ml
BSB 5006Concentrated1:250-1:10001.0 ml
BSB 5007Control Slides5


Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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