IHC of Bcl-X on an FFPE Hodgkin’s Lymphoma Tissue
|For In Vitro Diagnostic Use
|Summary and Explanation
|bcl-X, or bcl-2-like 1 protein, a member of the bcl-2 protein family, inhibits cell death, or apoptosis and func-tions as a regulator of apoptosis. bcl-X has two isoforms: bcl-XL (Long), a 241-amino acid protein; and bcl-XS (Short), a 178-amino acid protein lacking a 63-amino acid domain that is well conserved among members of the bcl-2 family. bcl-X is typically present in the cytosol in association with the mitochondrial membrane. bcl-XL forms heterodimers with various proteins, including Bax, Bak and bcl-2. It has been found that heterodimerization with Bax does not seem to be required for anti-apoptotic activity.
|Cytoplasmic and Cell/Nuclear Membrane
|Hodgkin’s Lymphoma, Kidney, Tonsil, Cervix
|Bcl-X is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.