IHC of Bcl-X on an FFPE Hodgkin’s Lymphoma Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | bcl-X, or bcl-2-like 1 protein, a member of the bcl-2 protein family, inhibits cell death, or apoptosis and func-tions as a regulator of apoptosis. bcl-X has two isoforms: bcl-XL (Long), a 241-amino acid protein; and bcl-XS (Short), a 178-amino acid protein lacking a 63-amino acid domain that is well conserved among members of the bcl-2 family. bcl-X is typically present in the cytosol in association with the mitochondrial membrane. bcl-XL forms heterodimers with various proteins, including Bax, Bak and bcl-2. It has been found that heterodimerization with Bax does not seem to be required for anti-apoptotic activity. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP94 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic and Cell/Nuclear Membrane | Control | Hodgkin’s Lymphoma, Kidney, Tonsil, Cervix | |||||||||||||||||||||||||||||||||
| Presentation | Bcl-X is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
| Availability |
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
