ALK/CD246 – RMab

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Alk-1-Rmab-40X-1Gfa26-1-1 Large Anaplastic Large Cell Lymphoma

IHC of ALK/CD246 on a FFPE Anaplastic Large Cell Lymphoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationAnaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK.This antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.
Antibody TypeRabbit MonoclonalCloneRBT-ALK1
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlAnaplastic Large Cell Lymphoma
PresentationAnti-ALK-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5043PredilutedReady-To-Use3.0 ml
BSB 5044PredilutedReady-To-Use7.0 ml
BSB 5045PredilutedReady-To-Use15.0 ml
BSB 5046Concentrated1:100-1:5000.1 ml
BSB 5047Concentrated1:100-1:5000.5 ml
BSB 5048Concentrated1:100-1:5001.0 ml
BSB 5049Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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