ZAP-70 – MMab

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ZAP70-40X-1FDJ22-35-2 Tonsil

IHC of ZAP-70 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation ZAP-70 is an abbrevation for Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa). The protein is a member of the protein-tyrosine kinase family. ZAP-70 is normally expressed in T-cells and natural killer cells and has a critical role in the initiation of T-cell signaling. ZAP-70 in B-cells is used as a prognostic marker in identifying different forms of Chronic Lymphocytic Leukemia (CLL). ZAP-70 protein is expressed in leukemic cells in approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between
the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.
Antibody Type Mouse Polyclonal Clone 2F3.2
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node, Chronic Lymphocytic Leukemia
Presentation ZAP-70 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6036 Prediluted Ready-To-Use 3.0 ml
BSB 6037 Prediluted Ready-To-Use 7.0 ml
BSB 6038 Prediluted Ready-To-Use 15.0 ml
BSB 6039 Concentrated 1:250-1:1000 0.1 ml
BSB 6040 Concentrated 1:250-1:1000 0.5 ml
BSB 6041 Concentrated 1:250-1:1000 1.0 ml
BSB 6042 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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