Alpha-1-Antitrypsin – Rabbit Polyclonal

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A-1-Antitrypsin-40X-1Wel23-18-1 Tonsil

IHC of Alpha-1-Antitrypsin on a FFPE Bladder Tonsil Tissue

United States
Research Use
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationAlpha-1-Antitrypsin (A1AT) is a glycoprotein generally known as serum trypsin inhibitor. Alpha-1-Antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it is a serine protease inhibitor (serpin), inhibiting a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially elastase, and has a reference range in blood of 1.5 – 3.5 gram/liter (in the U.S. the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise many fold upon acute inflammation. In its absence, elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (Chronic Obstructive Pulmonary Disease) in adults and cirrhosis in adults or children. Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT defi ciency, benign and Malignant Hepatic Tumors and Yolk-Sac Carcinomas. Positive staining for A-1-Antitrypsin may also be used in detection of benign and malignant lesions of a histiocytic nature. Sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with Cryptogenic Cirrhosis or other forms of liver disease with portal fibrosis of unknown etiology.
Antibody TypeRabbit PolyclonalCloneN/A
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlTonsil, Lymph Node
PresentationAlpha-1-Antitrypsin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Special NoteConcentrated Alpha-1-Antitrypsin antibody should be diluted to its working dilution in ImmunoDNA Background Blocker (Cat.# BSB 0103, BSB 0104, BSB 0105, BSB 0106 or BSB 0107)
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5008PredilutedReady-To-Use3.0 ml
BSB 5009PredilutedReady-To-Use7.0 ml
BSB 5010PredilutedReady-To-Use15.0 ml
BSB 5011Concentrated1:250-1:10000.1 ml
BSB 5012Concentrated1:250-1:10000.5 ml
BSB 5013Concentrated1:250-1:10001.0 ml
BSB 5014Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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