Amyloid Beta – RMab

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Ihc Of Amyloid Beta On An Ffpe Astrocytoma Tissue

IHC of Amyloid Beta on an FFPE Astrocytoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationAmyloid beta (Aβ or Abeta) consists of peptides of 36–43 amino acids that are crucially involved in Alzheimer’s disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP). Amyloid beta circulates in plasma, cerebrospinal fluid (CSF) and brain interstitial fluid (ISF) mainly as soluble Aβ40. Amyloid beta is the main constituent of brain parenchyma and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic.

Brain Amyloid beta is elevated in patients with sporadic Alzheimer’s disease and is the main component of amyloid plaques. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, while Amyloid beta can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases.

The mechanism by which Amyloid beta may damage and kill neurons is by generating reactive oxygen species during the process of its self-aggregation. It has been reported that amyloid beta production follows a circadian rhythm, rising when an animal or a person is awake and falling during sleep. The wakefulness-promoting neuroprotein orexin has been shown to be necessary for the circadian rhythm of amyloid beta production. This is consistent with recent findings that chronic sleep deprivation is associated with early onset Alzheimer’s disease.

Antibody TypeRabbit MonoclonalCloneRBT-A4
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlTestis, Kidney, Pancreas, Salivary Gland, Alzheimer’s Disease
PresentationAmyloid Beta is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3441PredilutedReady-To-Use3.0 ml
BSB 3442PredilutedReady-To-Use7.0 ml
BSB 3443PredilutedReady-To-Use15.0 ml
BSB 3444Concentrated1:50-1:2000.1 ml
BSB 3445Concentrated1:50-1:2000.5 ml
BSB 3446Concentrated1:50-1:2001.0 ml
BSB 3447Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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