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Amyloid Beta – RMab

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IHC of Amyloid Beta on an FFPE Astrocytoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Amyloid beta (Aβ or Abeta) consists of peptides of 36–43 amino acids that are crucially involved in Alzheimer’s disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP). Amyloid beta circulates in plasma, cerebrospinal fluid (CSF) and brain interstitial fluid (ISF) mainly as soluble Aβ40. Amyloid beta is the main constituent of brain parenchyma and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic.

Brain Amyloid beta is elevated in patients with sporadic Alzheimer’s disease and is the main component of amyloid plaques. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, while Amyloid beta can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases.

The mechanism by which Amyloid beta may damage and kill neurons is by generating reactive oxygen species during the process of its self-aggregation. It has been reported that amyloid beta production follows a circadian rhythm, rising when an animal or a person is awake and falling during sleep. The wakefulness-promoting neuroprotein orexin has been shown to be necessary for the circadian rhythm of amyloid beta production. This is consistent with recent findings that chronic sleep deprivation is associated with early onset Alzheimer’s disease.

Antibody Type Rabbit Monoclonal Clone RBT-A4
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Testis, Kidney, Pancreas, Salivary Gland, Alzheimer’s Disease
Presentation Amyloid Beta is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3441 Prediluted Ready-To-Use 3.0 ml
BSB 3442 Prediluted Ready-To-Use 7.0 ml
BSB 3443 Prediluted Ready-To-Use 15.0 ml
BSB 3444 Concentrated 1:50-1:200 0.1 ml
BSB 3445 Concentrated 1:50-1:200 0.5 ml
BSB 3446 Concentrated 1:50-1:200 1.0 ml
BSB 3447 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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