Annexin-A1 – MMab

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Annexin A1

IHC of Annexin A1 on a FFPE Hairy Cell Leukemia Tissue

United States
Research Use
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationThe protein Annexin A1 is encoded by the ANXA1 gene, which is upregulated in hairy cell leukemia. Annexin A1 inhibits the NF-kB signal transduction pathway (which is exploited by cancerous cells to proliferate and avoid apoptosis) by binding to the p65 subunit, and has been of interest for use as a potential anti-cancer drug. It may also contain tumor suppressive and protective characteristics, which have been evidenced by its ability to protect against DNA damage induced by heat in breast cancer cells.
Annexin A1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia. By contrast, B-cell lymphomas other than hairy cell leukemia are ANXA1 negative. Thus, ANXA1 is a molecule specific to hairy cell leukemia that can be used to differentiate this disease from other B-cell lymphomas.
Antibody TypeMouse MonoclonalCloneBSB-95
IsotypeIgG2bReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlLiver, Tonsil, Spleen, Tymus, Lung, Colon, Hairy Cell Leukemia
PresentationAnnexin-A1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6359PredilutedReady-To-Use3.0 ml
BSB 6360PredilutedReady-To-Use7.0 ml
BSB 6361PredilutedReady-To-Use15.0 ml
BSB 6362Concentrated1:100-1:5000.1 ml
BSB 6363Concentrated1:100-1:5000.5 ml
BSB 6364Concentrated1:100-1:5001.0 ml
BSB 6365Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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