Actin, Muscle-Specific – MMab

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Actin Hhf35-40X-1Zde30-2-1 Appendix

IHC of Actin, Muscle-Specific on an FFPE Skeletal Muscle Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationActin is a globular-structural, 345 kDa protein that polymerizes in a helical fashion to form an actin filament (or microfilament). Actin filaments provide mechanical support for the cell, determine the cell shape, enable cell movements (through lamellipodia, filopodia, or pseudopodia); and participate in certain cell junctions, in cytoplasmic streaming and in contraction of the cell during cytokinesis. In muscle cells they play an essential role, along with myosin, in muscle contraction. In the cytosol, actin is predominantly bound to ATP, but can also bind to ADP. This antibody recognizes actin of skeletal, cardiac, and smooth-muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Muscle-Specific Actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are nonreactive. Neoplastic cells of non-muscle-derived tissue such as Carcinomas, Melanomas and Lymphomas are
negative. This antibody is useful in the identification of rhabdoid cellular elements.
Antibody TypeMouse MonoclonalCloneHHF-35
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlSkeletal Muscle, Appendix, Prostate
PresentationActin, Muscle Specific is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5022PredilutedReady-To-Use3.0 ml
BSB 5023PredilutedReady-To-Use7.0 ml
BSB 5024PredilutedReady-To-Use15.0 ml
BSB 5025Concentrated1:50-1:2000.1 ml
BSB 5026Concentrated1:50-1:2000.5 ml
BSB 5027Concentrated1:50-1:2001.0 ml
BSB 5028Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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