Arginase-1 – RMab

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IHC of Arginase-1 on a FFPE Hepatocellular Carcinoma Tissue

United States
Research Use
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationArginase-1 is the catalyst for the fifth and final step in the urea cycle, which is a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. Arginase-1 works to convert L-arginine into L-ornithine and urea. Arginise-1 is located primarily in the cytoplasm of the liver. Arginase-1 consists of three tetramers, and the enzyme requires a two-molecule metal clusterof manganese in order to maintain proper function. These Mn2+ ions coordinate with water, orienting and stabilizing the molecule and allowing water to act as anucelophile and attack L-arginine, hydrolyzing it into ornithine and urea.Arginase-1 is abundantly expressed in the liver and it represents a sensitive and specific marker of benign and malignant hepatocytes. In sections of normal liver, anti-arginase 1 produces strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In a small percentage of cases, patchy nuclear reactivityis also evident in hepatocytes along with the strong cytoplasmic reactivity. Hepatocellular carcinoma usually shows higher protein expression of ARG1 than normal liver cells
Antibody TypeRabbit MonoclonalCloneEP 261
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlLiver, Hepatocellular Carcinoma
PresentationArginase-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5,
containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2447PredilutedReady-To-Use3.0 ml
BSB 2448PredilutedReady-To-Use7.0 ml
BSB 2449PredilutedReady-To-Use15.0 ml
BSB 2450Concentrated1:50-1:2000.1 ml
BSB 2451Concentrated1:50-1:2000.5 ml
BSB 2452Concentrated1:50-1:2001.0 ml
BSB 2453Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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