ALK – RMab

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IHC of ALK on a FFPE Anaplastic Large Cell Lymphoma Tissue

United States
Research Use
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Anaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK.This antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.
Antibody Type Rabbit Monoclonal Clone EP302
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Anaplastic Large Cell Lymphoma
Presentation ALK is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2796 Prediluted Ready-To-Use 3.0 ml
BSB 2797 Prediluted Ready-To-Use 7.0 ml
BSB 2798 Prediluted Ready-To-Use 15.0 ml
BSB 2799 Concentrated 1:50-1:200 0.1 ml
BSB 2800 Concentrated 1:50-1:200 0.5 ml
BSB 2801 Concentrated 1:50-1:200 1.0 ml
BSB 2802 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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