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ALK – RMab

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IHC of ALK on a FFPE Anaplastic Large Cell Lymphoma Tissue

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Research Use
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Anaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK.This antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.
Antibody Type Rabbit Monoclonal Clone EP302
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Anaplastic Large Cell Lymphoma
Presentation ALK is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2796 Prediluted Ready-To-Use 3.0 ml
BSB 2797 Prediluted Ready-To-Use 7.0 ml
BSB 2798 Prediluted Ready-To-Use 15.0 ml
BSB 2799 Concentrated 1:50-1:200 0.1 ml
BSB 2800 Concentrated 1:50-1:200 0.5 ml
BSB 2801 Concentrated 1:50-1:200 1.0 ml
BSB 2802 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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