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Androgen Receptor – MMab

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Androgen-Receptor-MMab

IHC of Androgen on a FFPE Prostate Tissue

United States
International
Research Use
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation The androgen receptor (AR) is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone. The main function of the androgen receptor is as a DNA-binding transcription factor which regulates gene expression. However, the androgen receptor has additional functions independent of DNA binding. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and the brain. This antibody reacts with the androgen receptor and also with the newly-described A form of the receptor. This antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors. Abnormalities in the AR-signaling pathway have been linked to a number of diseases, including Prostate Cancer, Kennedy’s Disease and male infertility.
Antibody Type Mouse Monoclonal Clone BSB-4
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control Prostate, Prostatic Adenocarcinoma
Presentation Androgen receptor is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6071 Prediluted Ready-To-Use 3.0 ml
BSB 6072 Prediluted Ready-To-Use 7.0 ml
BSB 6073 Prediluted Ready-To-Use 15.0 ml
BSB 6074 Concentrated 1:100-1:500 0.1 ml
BSB 6075 Concentrated 1:100-1:500 0.5 ml
BSB 6076 Concentrated 1:100-1:500 1.0 ml
BSB 6077 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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