IHC of ALDH1A1 on a FFPE Kidney Tissue
|For In Vitro Diagnostic Use.This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.* The ALDH1A1 antibody, clone EP168, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409.
|Summary and Explanation
|Aldehyde dehydrogenase 1 family member A1, also known as ALDH1A1 is an enzyme that in humans is encoded by the Aldh1A1 gene on chromosome 9. ALDH1A1 belongs to the aldehyde dehydrogenase family, which plays a role in alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver; cytosolic and mitochondrial. The ALDH1A1 gene encodes the cytosolic isozyme, and catalyzes the oxidation of retinaldehyde to retinoic acid. Studies have indicated that ALDH1A1 may also be involved in the regulation of the metabolic responses to high-fat diet. ALDH1A1 has been a well established marker of hematopoietic stem cells and progenitor cells. Recent studies also show that ALDH1A1 is an important cancer stem marker associated with tumor progression in cancers of the breast, prostate and lung. This antibody labels epithelial cells of the stomach, liver, kidney and thyroid, neural cells and stromal cells including endothelial cells. In tumors, it stains stromal cells as well as tumor cells in many types of cancers. ALDH1A1 can be used with CD34 to aid in the differentiation between solitary fibrous tumors, hemangiopericytoma, meningioma and synovial sarcomas.
|Kidney, Liver, Testis, Colon Cancer, Breast Cancer
|Aldh1A1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge use to ensure recovery of all product.