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Alpha Synuclein – MMab

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IHC of Alpha Synuclein on a FFPE Astrocytoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Alpha-synuclein is a 140 amino acids protein encoded by the SNCA gene. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum with smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly in presynaptic terminals.

An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer’s disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. Alpha-synuclein aggregates to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. These disorders are known as synucleinopathies. Occasionally,
Lewy bodies contain tau protein; however, alpha-synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies.

Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer’s disease. In rare cases of familial forms of Parkinson’s disease, there is a mutation in the gene coding for alpha-synuclein. Genomic duplication and triplication of the gene appear to be a rare cause of Parkinson’s disease in other lineages, although more common than point mutations. Hence certain mutations of alpha-synuclein may cause it to form amyloid-like fibrils that contribute to Parkinson’s disease.

Antibody Type Mouse Monoclonal Clone BSB-114
Isotype IgG2a/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Brain, Breast, Skin, Tonsil, Bone Marrow, Alzheimer’s Disease, Parkinson’s Disease
Presentation Alpha Synuclein is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3286 Prediluted Ready-To-Use 3.0 ml
BSB 3287 Prediluted Ready-To-Use 7.0 ml
BSB 3288 Prediluted Ready-To-Use 15.0 ml
BSB 3289 Concentrated 1:25-1:100 0.1 ml
BSB 3290 Concentrated 1:25-1:100 0.5 ml
BSB 3291 Concentrated 1:25-1:100 1.0 ml
BSB 3292 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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