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Alpha-Methylacyl-CoA Racemace – RMab

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Alpha-Methylacyl-CoA-Racemase-RMab

IHC of AMACR on a FFPE Prostatoc Adenocarcinoma Tissue

United States
International
Research Use
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker.High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34βE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.
Antibody Type Rabbit Monoclonal Clone 13H4
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Kidney, Liver, Salivary Gland, Prostate Lesions, Prostatic Adenocarcinoma
Presentation P504S/AMACR is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5057 Prediluted Ready-To-Use 3.0 ml
BSB 5058 Prediluted Ready-To-Use 7.0 ml
BSB 5059 Prediluted Ready-To-Use 15.0 ml
BSB 5060 Concentrated 1:25-1:100 0.1 ml
BSB 5061 Concentrated 1:25-1:100 0.5 ml
BSB 5062 Concentrated 1:25-1:100 1.0 ml
BSB 5063 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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