Alpha-Methylacyl-CoA Racemace – RMab

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IHC of AMACR on a FFPE Prostatoc Adenocarcinoma Tissue

United States
Research Use
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationAMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker.High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34βE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.
Antibody TypeRabbit MonoclonalClone13H4
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlKidney, Liver, Salivary Gland, Prostate Lesions, Prostatic Adenocarcinoma
PresentationP504S/AMACR is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5057PredilutedReady-To-Use3.0 ml
BSB 5058PredilutedReady-To-Use7.0 ml
BSB 5059PredilutedReady-To-Use15.0 ml
BSB 5060Concentrated1:25-1:1000.1 ml
BSB 5061Concentrated1:25-1:1000.5 ml
BSB 5062Concentrated1:25-1:1001.0 ml
BSB 5063Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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