IHC of CD4 on an FFPE Tonsil Tissue
|For In Vitro Diagnostic Use
|Summary and Explanation
|CD4 is a glycoprotein expressed on the surface of T-helper cells, regulatory T-cells, monocytes, macrophages, and dendritic cells. On T-cells, CD4 is the co-receptor for the T-cell receptor (TCR). It amplifies the signal gener-ated by the TCR by recruiting the tyrosine kinase that is essential for activating many molecules involved in the signaling cascade of an activated T-cell. CD4 antigen is involved in the recognition of Type II Major Histocompatability Complex antigens (MHC-II). CD4 is also the receptor for Human Immunodeficiency Virus (HIV). It is present on most T-helper cells and normal thymocytes.
|Tonsil, Lymph Node
|CD4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.