bcl-10 – MMab

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Bcl10-40X-1Mea20-39 Tonsil

IHC of Bcl-10 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and Explanationbcl-10 (also known as B-cell lymphoma/leukemia 10) is a 233 amino acid protein encoded by the BCL10 gene on Chromosome 1. The protein encoded by this gene contains a caspase recruitment domain , and has been shown to induce apoptosis and activate NF-kappaB. This protein is reported to interact with caspase recruitment domains (CARD) containing proteins including CARD9, 10, 11 and 14. These proteins function as upstream regulators in NF-kappaB signaling.Studies have shown that bcl-10 plays a critical role in the development of mucosa associated lymphoma tissue (MALT) lymphoma, and can be utilized in the classification of lymphomas. The antibody labels subpopulations of normal B and T cells. In MALT lymphomas with the t(1;14) translocation, the antibody strongly labeled the nuclei and cytoplasm, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Antibody TypeMouse MonoclonalCloneBSB-22
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationNuclear, CytoplasmicControlTonsil, Kidney, Cervix, bladder TCC, MALT Lymphomas
Presentationbcl-10 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2698PredilutedReady-To-Use3.0 ml
BSB 2699PredilutedReady-To-Use7.0 ml
BSB 2700PredilutedReady-To-Use15.0 ml
BSB 2701Concentrated1:100-1:5000.1 ml
BSB 2702Concentrated1:100-1:5000.5 ml
BSB 2703Concentrated1:100-1:5001.0 ml
BSB 2704Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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