TTF-1 – MMab

IHC of TTF-1 on an FFPE Lung Tissue

IHC of TTF-1 on an FFPE Lung Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific to the thyroid, lung and diencephalon. It is also known as thyroid-specific enhancer binding protein and NKX-2. It is used as a marker to determine if a tumor oringinates in the lung or thyroid. TTF-1 positive cells are found in Type II pneumocytes and Clara cells in the lung. In the thyroid, follicular and parafollicular cells are positive. TTF-1 is useful in differentiating primary Adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. It can also be used to differentiate Small- Cell Lung Carcinoma from lymphoid infiltrates. For lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. Small-Cell Carcinomas (of any primary site) are usually positive.
Antibody Type Mouse Monoconal Clone 8G7G3/1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control Adenocarcinoma of Lung, Normal Lung, Thyroid
Presentation TTF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6001 Prediluted Ready-To-Use 3.0 ml
BSB 6002 Prediluted Ready-To-Use 7.0 ml
BSB 6003 Prediluted Ready-To-Use 15.0 ml
BSB 6004 Concentrated 1:250-1:1000 0.1 ml
BSB 6005 Concentrated 1:250-1:1000 0.5 ml
BSB 6006 Concentrated 1:250-1:1000 1.0 ml
BSB 6007 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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