Treponema Pallidum – Polyclonal

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3. Ihc Of Treponema Pallidum On A Ffpe Infected Skin Tissue Webpage

IHC of Treponema pallidum on an FFPE Infected Skin Tissue

United States
Research Use
Safety Data Sheet
Control Slides
Intended UseFor Analyte Specific Reagent
Summary and Explanation

Treponema pallidum is a spirochaete bacterium. The treponemes have a cytoplasmic and an outer membrane. The shape of T. pallidum is flat and wavy, unlike the other spirochetes, which are helical. Using light microscopy, treponemes are only visible using dark field illumination. They are Gram negative, but some regard them too thin to be Gram stained. T. pallidum is a motile spirochaete that is generally acquired by close sexual contact, entering the host via breaches in squamous or columnar epithelium. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, giving rise to congenital syphilis. The helical structure of T. pallidum allows it to move in a corkscrew motion through a viscous medium such as mucus. It gains access to the host’s blood and lymph systems through tissue and mucous membranes.

Detection of Treponema pallidum can be difficult, and the correct diagnosis of secondary syphilis is critical. Diagnosis of syphilis is usually based on clinical presentation, dark-field microscope analysis, and serological tests. T. pallidum can be also evidenced by Immunohistochemistry in up to 90% of the samples with the bacteria located in the epidermis and the upper dermis of formalin-fixed paraffin-embedded tissues.

Antibody TypeRabbit PolyclonalClonePolyclonal
IsotypeIgGReactivityParaffin, Frozen
LocalizationCell WallControlTreponema pallidum infected tissue

Treponema pallidumid a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3232PredilutedReady-To-Use3.0 ml
BSB 3233PredilutedReady-To-Use7.0 ml
BSB 3234PredilutedReady-To-Use15.0 ml
BSB 3235Concentrated1:250-1:10000.1 ml
BSB 3236Concentrated1:250-1:10000.5 ml
BSB 3237Concentrated1:250-1:10001.0 ml
BSB 3238Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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