TLE1 – MMab

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Ihc Of Tle1 On An Ffpe Synovial Sarcoma Tissue

IHC of TLE1 on an FFPE Synovial Sarcoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationThe Notch signaling pathway controls cellular interactions important for the specifi cation of a variety of fates
in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes. TLEs associate
with chromatin in live cells and specifi cally with Histone H3, but not with other core histones. Expression of
the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward
a terminally diff erentiated state, suggesting a role during epithelial diff erentation.
Anti-TLE1 can be used to diff erentiate synovial sarcoma from other sarcomas, including histologically similar
tumors such as malignant peripheral nerve sheath tumor.
Antibody TypeMouse MonoclonalClone1F5
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmic, NuclearControlSynovial Sarcoma
PresentationTLE1 is a Mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2314PredilutedReady-To-Use3.0 ml
BSB 2315PredilutedReady-To-Use7.0 ml
BSB 2316PredilutedReady-To-Use15.0 ml
BSB 2317Concentrated1:10-1:500.1 ml
BSB 2318Concentrated1:10-1:500.5 ml
BSB 2319Concentrated1:10-1:501.0 ml
BSB 2320Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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