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Thyroid Peroxidase – RMab

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IHC of Thyroid Peroxidase on an FFPE Thyroid Adenoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation
Thyroid Peroxidase (TPO) is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene. The TPO gene consists of 17 exons, and is located on the short arm of chromosome 2.
Thyroid Peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of TPO described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. TPO labels normal thyroid epithelial cells and thyroid tumor cells.The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. Decreased TPO immunoreactivity is an early event in follicular tumourigenesis, taking place before development of invasiveness in parallel with an acceleration of cell growth and appearance of cell atypia.
Antibody Type Rabbit Monoclonal Clone EP159
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control
Thyroid, Thyroid Carcinoma
Presentation Thyroid Peroxidase is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2615 Prediluted Ready-To-Use 3.0 ml
BSB 2616 Prediluted Ready-To-Use 7.0 ml
BSB 2617 Prediluted Ready-To-Use 15.0 ml
BSB 2618 Concentrated 1:100-1:500 0.1 ml
BSB 2619 Concentrated 1:100-1:500 0.5 ml
BSB 2620 Concentrated 1:100-1:500 1.0 ml
BSB 2621 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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