Thyroid Peroxidase – RMab

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Thyroid Peroxidase Rmab Ivd

IHC of Thyroid Peroxidase on an FFPE Thyroid Adenoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and Explanation
Thyroid Peroxidase (TPO) is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene. The TPO gene consists of 17 exons, and is located on the short arm of chromosome 2.
Thyroid Peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of TPO described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. TPO labels normal thyroid epithelial cells and thyroid tumor cells.The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. Decreased TPO immunoreactivity is an early event in follicular tumourigenesis, taking place before development of invasiveness in parallel with an acceleration of cell growth and appearance of cell atypia.
Antibody TypeRabbit MonoclonalCloneEP159
IsotypeIgGReactivityParaffin, Frozen
Thyroid, Thyroid Carcinoma
PresentationThyroid Peroxidase is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2615PredilutedReady-To-Use3.0 ml
BSB 2616PredilutedReady-To-Use7.0 ml
BSB 2617PredilutedReady-To-Use15.0 ml
BSB 2618Concentrated1:100-1:5000.1 ml
BSB 2619Concentrated1:100-1:5000.5 ml
BSB 2620Concentrated1:100-1:5001.0 ml
BSB 2621Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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