Synaptophysin – Rabbit Polyclonal

Ihc Of Synaptophysin On An Ffpe Neuroendocrine Tumor

IHC of Synaptophysin on an FFPE Neuroendocrine Tumor

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationSynaptophysin is a synaptic vesicle glycoprotein weighing 38 kDa. It is present in endocrine cells, the brain, spinal cord, and adrenal glands. It acts as a marker for neuroendocrine cells. Synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth’s cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely-granular cytoplasmic staining is observed and probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of Synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation.
Antibody TypeRabbit PolyclonalCloneN/A
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlPancreas, Brain, Pituitary, Adrenal, Colon
PresentationSynaptophysin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5945PredilutedReady-To-Use3.0 ml
BSB 5946PredilutedReady-To-Use7.0 ml
BSB 5947PredilutedReady-To-Use15.0 ml
BSB 5948Concentrated1:250-1:10000.1 ml
BSB 5949Concentrated1:250-1:10000.5 ml
BSB 5950Concentrated1:250-1:10001.0 ml
BSB 5951Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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