Survivin – RMab

Ihc Of Survivin On An Ffpe Colon Tissue

IHC of Survivin on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationSurvivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumors and fetal tissue, but is completely absent in terminally differentiated cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis.
The association of survivin expression with tumor progression, but not overall patient survival, has been observed in a variety of malignancies including renal cell carcinoma, ovary carcinoma, hepatocellular carcinoma, prostate carcinoma and breast carcinoma.
Antibody TypeRabbit MonoclonalCloneEP119
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlColon, Placenta, Testis, Tonsil, Bone Marrow, Colon Carcinoma, Lymphoblastic Lymphoma, Bladder TCC
PresentationSurvivin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2223PredilutedReady-To-Use3.0 ml
BSB 2224PredilutedReady-To-Use7.0 ml
BSB 2225PredilutedReady-To-Use15.0 ml
BSB 2226Concentrated1:50-1:2000.1 ml
BSB 2227Concentrated1:50-1:2000.5 ml
BSB 2228Concentrated1:50-1:2001.0 ml
BSB 2229Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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