SOX-2 – RMab

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Ihc Of Sox-2 On An Ffpe Brain Tissue

IHC of SOX-2 on an FFPE Brain Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationSRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. It is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach.
SOX2 is expressed in fetal brain and is used as a marker for multipotential neural stem cells. In tumors, SOX2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract. SOX2 may be useful in the identification of embryonal carcinoma. In stage I lung adenocarcinomas, SOX2 seems to be an independent predictor of poor outcome and may help stratify patients at increased risk for recurrence.
Antibody TypeRabbit MonoclonalCloneEP103
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlSquamous Cell Carcinoma, Brain, Oligodendroglioma
PresentationSOX-2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2202PredilutedReady-To-Use3.0 ml
BSB 2203PredilutedReady-To-Use7.0 ml
BSB 2204PredilutedReady-To-Use15.0 ml
BSB 2205Concentrated1:50-1:2000.1 ml
BSB 2206Concentrated1:50-1:2000.5 ml
BSB 2207Concentrated1:50-1:2001.0 ml
BSB 2208Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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