PAX-8 – RMab

3. Ihc Pax 8 Rmab On A Ffpe Ovarian Carcinoma Tissue Webpage

IHC of PAX-8 on an FFPE Ovarian Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 expression in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities.

PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast.

Antibody TypeRabbit MonoclonalCloneEP298
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlOvary Thyroid
PresentationPAX-8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 3141PredilutedReady-To-Use3.0 ml
BSB 3142PredilutedReady-To-Use7.0 ml
BSB 3143PredilutedReady-To-Use15.0 ml
BSB 3144Concentrated1:50-1:2000.1 ml
BSB 3145Concentrated1:50-1:2000.5 ml
BSB 3146Concentrated1:50-1:2001.0 ml
BSB 3147Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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