PAX-8 – RMab

IHC of PAX-8 on an FFPE Ovarian Carcinoma Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation

PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 expression in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities.

PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast.

Antibody Type Rabbit Monoclonal Clone EP298
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Ovary Thyroid
Presentation PAX-8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3141 Prediluted Ready-To-Use 3.0 ml
BSB 3142 Prediluted Ready-To-Use 7.0 ml
BSB 3143 Prediluted Ready-To-Use 15.0 ml
BSB 3144 Concentrated 1:50-1:200 0.1 ml
BSB 3145 Concentrated 1:50-1:200 0.5 ml
BSB 3146 Concentrated 1:50-1:200 1.0 ml
BSB 3147 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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