p53 – MMab

Ihc Of P53 On An Ffpe Breast Carcinoma Tissue

IHC of p53 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanationp53 (also known as tumor protein 53 [TP53]) is a transcription factor that regulates the cell cycle and, hence, functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA has sustained damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death, if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms. It can induce growth arrest, apoptosis and cell senescence. Mutations involving p53 have been found in a wide variety of malignant tumors, including Breast, Ovarian, Bladder, Colon, Lung, and Melanoma.
Antibody TypeMouse MonoclonalCloneDO7
IsotypeIgG2b/KReactivityParaffin, Frozen
LocalizationNuclearControlLung, Breast, Ovarian, Prostate, Colon Carcinoma
Presentationp53 clone DO7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5841PredilutedReady-To-Use3.0 ml
BSB 5842PredilutedReady-To-Use7.0 ml
BSB 5843PredilutedReady-To-Use15.0 ml
BSB 5844Concentrated1:250-1:10000.1 ml
BSB 5845Concentrated1:250-1:10000.5 ml
BSB 5846Concentrated1:250-1:10001.0 ml
BSB 5847Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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