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OLIG2 – RMab

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IHC of OLIG2 on an FFPE Brain Tissue

IHC of OLIG2 on an FFPE Brain Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the Olig2 gene. The protein is of 329 amino acids in length, 32kDa in size and contains 1 basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3. The expression of OLIG2 is mostly restricted in central nervous system, where it acts as both an anti-neurigenic and a neurigenic factor at different stages of development. OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development.No OLIG2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, subependymomas, medulloblastomas, and non-neuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas. Compared to the strong staining seen in glioma samples, a weak expression is observed in nontumoral brain tissue (gliosis). OLIG2 is universally expressed in glioblastoma and other diffuse gliomas (astrocytomas, oligodendrogliomas and oligoastrocytomas), and is a useful positive diagnostic marker of these brain tumors.
Antibody Type Rabbitt Monoclonal Clone EP112
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control
Brain, Astrocytoma
Presentation Anti-OLIG2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2559 Prediluted Ready-To-Use 3.0 ml
BSB 2560 Prediluted Ready-To-Use 7.0 ml
BSB 2561 Prediluted Ready-To-Use 15.0 ml
BSB 2562 Concentrated 1:50-1:200 0.1 ml
BSB 2563 Concentrated 1:50-1:200 0.5 ml
BSB 2563 Concentrated 1:50-1:200 1.0 ml
BSB 2564 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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