OLIG2 – RMab

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Ihc Of Olig2 On An Ffpe Brain Tissue

IHC of OLIG2 on an FFPE Brain Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationOligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the Olig2 gene. The protein is of 329 amino acids in length, 32kDa in size and contains 1 basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3. The expression of OLIG2 is mostly restricted in central nervous system, where it acts as both an anti-neurigenic and a neurigenic factor at different stages of development. OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development.No OLIG2 expression has been found in the non-glial tumors including neuroepithelial tumors, ependymomas, subependymomas, medulloblastomas, and non-neuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid/rhabdoid tumor, and haemangioblastomas. Compared to the strong staining seen in glioma samples, a weak expression is observed in nontumoral brain tissue (gliosis). OLIG2 is universally expressed in glioblastoma and other diffuse gliomas (astrocytomas, oligodendrogliomas and oligoastrocytomas), and is a useful positive diagnostic marker of these brain tumors.
Antibody TypeRabbitt MonoclonalCloneEP112
IsotypeIgGReactivityParaffin, Frozen
Brain, Astrocytoma
PresentationAnti-OLIG2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2559PredilutedReady-To-Use3.0 ml
BSB 2560PredilutedReady-To-Use7.0 ml
BSB 2561PredilutedReady-To-Use15.0 ml
BSB 2562Concentrated1:50-1:2000.1 ml
BSB 2563Concentrated1:50-1:2000.5 ml
BSB 2563Concentrated1:50-1:2001.0 ml
BSB 2564Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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