NSE – MMab

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Ihc Of Nse On An Ffpe Pancreas Tissue

IHC of NSE on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationNeuron-Specific Enolase (NSE, Enolase 2) is a human gene. It makes a phosphopyruvate hydratase. This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. NSE is present in high concentration in neurons and in central and peripheral neuroendocrine cells; therefore, NSE reacts with cells of neural and neuroendocrine lineage. If neoplastic cells coexpress keratins and NSE, neuroendocrine differentiation is probable. However, neural tumors that do not express keratin, and show no staining with NSE, would not exclude neural or neuroendocrine differentiation. Thus, detection of neural and neuroendocrine lineage requires the use of panels which include NSE and other markers such as keratin, chromogranin, synaptophysin and neurofilament.
Antibody TypeMouse MonoclonalCloneBSB-94
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlPancreas, Brain, Pituitary, Adrenal, Thyroid
PresentationNSE is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5820PredilutedReady-To-Use3.0 ml
BSB 5821PredilutedReady-To-Use7.0 ml
BSB 5822PredilutedReady-To-Use15.0 ml
BSB 5823Concentrated1:100-1:5000.1 ml
BSB 5824Concentrated1:100-1:5000.5 ml
BSB 5825Concentrated1:100-1:5001.0 ml
BSB 5826Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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