MUC4 – MMab

1. Ihc Of Muc4 On A Ffpe Colon Tissue Spec Catalog

IHC of MUC4 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and Explanation

Mucin 4 (MUC4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC4 is a high-molecular weight glycoprotein.  MUC4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein. MUC4 antibody labels normal epithelial cells in the trachea, GI tract  and prostate, but not in the pancreas.

MUC-4 has been found to play various roles in the progression of cancer, particularly due to its signaling and anti-adhesive properties which contribute to tumor development and metastasis. It is also found to play roles in other diseases such as endometriosis and inflammatory bowel disease. An abnormal expression of MUC4 has been reported in various carcinomas of the colon, pancreas, breast, and ovaries. Increased expression of MUC4 has been observed in pancreatic carcinoma and cervical squamous carcinoma. MUC4 is helpful in differentiating lung adenocarcinoma (positive) from malignant mesothelioma (negative). Additionally, MUC4 is useful in the identification of low-grade fibromyxoid sarcoma (LGFMS), and sclerosing epithelioid fibrosarcoma. MUC4 expression is also detected in the glandular component of biphasic synovial sarcomas.

Antibody TypeMouse MonoclonalClone8G7
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmicControlColon, Placenta, Breast, Cervix, Fallopian Tube, Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma
PresentationMUC4 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2985PredilutedReady-To-Use3.0 ml
BSB 2986PredilutedReady-To-Use7.0 ml
BSB 2987PredilutedReady-To-Use15.0 ml
BSB 2988Concentrated1:25-1:1000.1 ml
BSB 2989Concentrated1:25-1:1000.5 ml
BSB 2990Concentrated1:25-1:1001.0 ml
BSB 2991Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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