MCM2 – RMab

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Mcm2 10X 1Mei18 23 2 Anal Carcinoma2

IHC of MCM2 on an FFPE Anal Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationMCM-2 (mini-chromosome maintenance 2) is a human gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex, and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM-4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by protein kinases CDC2 and CDC7.MCM-2 is essential for eukaryotic DNA replication and drives the formation of pre-replicative complexes, which is the key first step during the G1 phase. Therefore, altered MCM-2 expression may be a hallmark of cell-cycle deregulation, which could be the most essential mechanism in the development and progression of human cancers. MCM2 has been identified by DNA microarray and transcriptional profiling as a gene that is over-expressed in Cervical Carcinomas. This protein is over-expressed in Cervical Dysplasia as a result of HPV infection. The over-expression of MCM-2 provides the link between oncogenic HPV infection and the molecular event of Cervical Dysplasia.
Antibody TypeRabbit MonoclonalCloneRBT-MCM2
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlHSIL, Cervical and Breast Cancer
PresentationMCM2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6331PredilutedReady-To-Use3.0 ml
BSB 6332PredilutedReady-To-Use7.0 ml
BSB 6333PredilutedReady-To-Use15.0 ml
BSB 6334Concentrated1:100-1:5000.1 ml
BSB 6335Concentrated1:100-1:5000.5 ml
BSB 6336Concentrated1:100-1:5001.0 ml
BSB 6337Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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