Ksp-Cadherin – MMAb

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Ihc Of Ksp-Cadherin On An Ffpe Kidney Tissue

IHC of Ksp-Cadherin on an FFPE Kidney Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationKsp-Cadherin (Kidney-specific Cadherin) is a novel, kidney-specific member of the Cadherin family of cell-adhesion molecules. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different Cadherins, including E-Cadherin, Cadherin-6, and N-Cadherin, have been investigated in Renal Cell Cancers, demonstrating possible correlations of tumor differentiation and the presence of lymph node metastasis with loss of Cadherins. Ksp-Cadherin has been used to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Studies have found a membranous pattern of staining in 96% of 30 Chromophobe Carcinomas, and in only 6% of 31 Oncocytomas, leading to conclude that this is a useful antibody in differentiating these two lesions. On the other hand, another study found Ksp-Cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 Oncocytomas.
Antibody TypeMouse MonoclonalClone4H6/F9
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationMembranous, CytoplasmicControlThyroid, Kidney, Chromophobe Renal Cell Carcinoma
PresentationKsp-Cadherin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6282PredilutedReady-To-Use3.0 ml
BSB 6283PredilutedReady-To-Use7.0 ml
BSB 6284PredilutedReady-To-Use15.0 ml
BSB 6285Concentrated1:250-1:10000.1 ml
BSB 6286Concentrated1:250-1:10000.5 ml
BSB 6287Concentrated1:250-1:10001.0 ml
BSB 6288Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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