IgM – MMab

Ihc Of Igm On An Ffpe Axilar Lymph Node With Metastatic Breast Carcinoma

IHC of IgM on an FFPE Axilar Lymph Node with Metastatic Breast Carcinoma

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationIgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. It has a large molecular mass of approximately 900 kDa (in its pentamer form). In germline cells, the gene segment encoding the constant region of the heavy chain is positioned first among other constant region gene segments. For this reason, IgM is the first immunoglobulin expressed by mature B-cells. IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes, and is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.
Antibody TypeMouse MonoclonalCloneBSB-41
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlTonsil, Lymph Node, Spleen, Kidney, Colon
PresentationIgM is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5680PredilutedReady-To-Use3.0 ml
BSB 5681PredilutedReady-To-Use7.0 ml
BSB 5682PredilutedReady-To-Use15.0 ml
BSB 5683Concentrated1:100-1:5000.1 ml
BSB 5684Concentrated1:100-1:5000.5 ml
BSB 5685Concentrated1:100-1:5001.0 ml
BSB 5686Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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