Glucagon – MMab

IHC of Uroplakin III on an FFPE Bladder TCC Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Glucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Abnormally-elevated levels of glucagon may be caused by pancreatic tumors such as glucagonoma, symptoms of which include necrolytic migratory erythema (NME), elevated amino acids and hyperglycemia. It may occur alone or in the context of Multiple Endocrine Neoplasia Type 1.

Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas. Studies show that approximately 80% of glucagonomas are malignant and these patients have a syndrome most often initially recognized by dermatologists. Symptoms include necrolytic migratory erythema as well as diabetes, anemia, stomatitis, weight loss, frequent venous thromboses, and in some instances, diarrhea and psychiatric disturbances. The diagnosis may be readily confirmed by the demonstration of elevated plasma glucagon concentration.

Antibody Type Mouse Monoclonal Clone BSB-111
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Pancreas, Colon
Presentation GlucagonI is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3342 Prediluted Ready-To-Use 3.0 ml
BSB 3343 Prediluted Ready-To-Use 7.0 ml
BSB 3344 Prediluted Ready-To-Use 15.0 ml
BSB 3345 Concentrated 1:250-1:1000 0.1 ml
BSB 3346 Concentrated 1:250-1:1000 0.5 ml
BSB 3347 Concentrated 1:250-1:1000 1.0 ml
BSB 3348 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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