IHC of FOXP3 on an FFPE Thymus Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
FOXP3, also known as scurfin, is a protein involved in immune system responses. A member of the forkhead box protein family, FOXP3 appears to function as a transcription factor in the development and function of regulatory T cells. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters of many important for regulatory T-cell function, and may repress transcription of key genes following stimulation of T cell receptors.
Alterations in numbers of regulatory T-cells – in particular those that express FOXP3 – are found in a number of disease states. Patients with tumors have a local relative excess of FOXP3 positive T cells which inhibits the body’s ability to suppress the formation of cancerous cells.
|Antibody Type||Rabbit Monoclonal||Clone||EP340|
|Localization||Nuclear||Control||Tonsil, Lymph Node, Thymus|
|Presentation||FOXP3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|