IHC of FOXA1 / HNF-3A on an FFPE Colon Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||
FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. FOXA1 is a downstream target of GATA3 in the mammary gland.
FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 absence in ERα+ cancer might identify ERa cancers that are resistant to endocrine therapy. In ERα− breast cancer, FOXA1 is highly correlated with improved disease free survival and GATA3. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.
|Antibody Type||Rabbit Monoclonal||Clone||EP277|
|Localization||Nuclear, Cytoplasmic||Control||Prostate, Breast, Tonsil, Colon, Fallopian Tube, Breast Carcinoma, Prostate Carcinoma|
|Presentation||FOXA1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|