DOG-1 – RMab

SKU: 182862001b75 Categories: , , , , ,

IHC of DOG-1 on an FFPE GIST Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis.
Antibody Type Rabbit Monoclonal Clone RBT-DOG1
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control GIST
Presentation DOG-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6268 Prediluted Ready-To-Use 3.0 ml
BSB 6269 Prediluted Ready-To-Use 7.0 ml
BSB 6270 Prediluted Ready-To-Use 15.0 ml
BSB 6271 Concentrated 1:100-1:500 0.1 ml
BSB 6272 Concentrated 1:100-1:500 0.5 ml
BSB 6273 Concentrated 1:100-1:500 1.0 ml
BSB 6274 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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