DOG-1 – RMab

SKU: 182862001b75 Categories: , , , , ,

Dog 1 Rmab

IHC of DOG-1 on an FFPE GIST Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationDOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis.
Antibody TypeRabbit MonoclonalCloneRBT-DOG1
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlGIST
PresentationDOG-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6268PredilutedReady-To-Use3.0 ml
BSB 6269PredilutedReady-To-Use7.0 ml
BSB 6270PredilutedReady-To-Use15.0 ml
BSB 6271Concentrated1:100-1:5000.1 ml
BSB 6272Concentrated1:100-1:5000.5 ml
BSB 6273Concentrated1:100-1:5001.0 ml
BSB 6274Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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