Cytokeratin 8 & 18 – RMab

Cytokeratin 8 18 Rmab

IHC of Cytokeratin 8 & 18 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCytokeratin 8 belongs to the Type II (basic) subfamily of high molecular-weight keratins and exists in combination with Cytokeratin 18 (Type I [acidic] subfamily of low molecular weight keratins). They are perhaps the most commonly found products of the intermediate filament gene family, and are expressed in single-layer epithelial tissues of the body.
Cytokeratins 8 and 18 can be found in most simple epithelium (e.g., thyroid, female breast, gastrointestinal tract, and respiratory tract). Adenocarcinomas and most Non-keratinizing Squamous Carcinomas will stain, but Keratinizing Squamous Carcinomas will not. This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells will stain. This approach facilitates the interpretation using immunostains and is more sensitive than mucin histochemistry.
Antibody TypeRabbit MonoclonalCloneEP17 & EP30
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlBreast, Ovary, GI, Prostate, Pancreas, Salivary Gland, Colon
PresentationCK8/18 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2049PredilutedReady-To-Use3.0 ml
BSB 2050PredilutedReady-To-Use7.0 ml
BSB 2051PredilutedReady-To-Use15.0 ml
BSB 2052Concentrated1:25-1:1000.1 ml
BSB 2053Concentrated1:25-1:1000.5 ml
BSB 2054Concentrated1:25-1:1001.0 ml
BSB 2055Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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