Products

Cytokeratin 5 & 14 – RMab

SKU: f8b40ab8dc3a Categories: , , ,

IHC of Cytokeratin 5 & 14 on an FFPE Breast Tissue

IHC of Cytokeratin 5 & 14 on an FFPE Breast Tissue Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 5 is a type II cytokeratin found in squamous cell epithelium, myoepithelial cells of the breast and the basal cells of the prostate. Cytokeratin 14 is a Type I polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Together, they form the cytoskeleton of epithelial cells.
Cytokeratin 5 is expressed in most Epithelial Mesotheliomas but not by most Pulmonary Adenocarcinomas and can be used to differentiate between the two. Cytokeratin 14 antibody labels the basal layer of stratifying squamous and non-squamous epithelia and recognizes Basal Cell Carcinomas and Squamous Cell Carcinomas. Anti-CK14 has been demonstrated to be useful in differentiating Squamous Cell Carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from renal mimics, as well as in determining metaplastic Carcinomas of the Breast. Anti- CK5, along with Anti-CK14, has found application in identifying the basaloid phenotype of breast carcinoma, a tumor with poor prognosis.
Antibody Type Rabbit Monoclonal Clone EP24/EP61
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast, Prostate, Skin, Prostatic carcinoma
Presentation CK 5 & 14 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6625 Prediluted Ready-To-Use 3.0 ml
BSB 6626 Prediluted Ready-To-Use 7.0 ml
BSB 6627 Prediluted Ready-To-Use 15.0 ml
BSB 6628 Concentrated 1:25-1:100 0.1 ml
BSB 6629 Concentrated 1:25-1:100 0.5 ml
BSB 6630 Concentrated 1:25-1:100 1.0 ml
BSB 6631 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

Related products