CDK4 – RMab

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Hc Of Cdk4 On A Ffpe Colon Carcinoma Tissue

IHC of CDK4 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a).Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression.
Binh et al. reported a high expression of CDK4 (92%) in atypical lipomatous tumor/well-differentiated liposarcomas (ALT-WDLPS) and dedifferentiated liposarcomas (DDLPS). CDK4 is useful in differentiating ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
Antibody TypeRabbit MonoclonalCloneEP180
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlSkin, Colon Carcinoma, Liposarcoma
PresentationCDK4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2461PredilutedReady-To-Use3.0 ml
BSB 2462PredilutedReady-To-Use7.0 ml
BSB 2463PredilutedReady-To-Use15.0 ml
BSB 2464Concentrated1:25-1:1000.1 ml
BSB 2465Concentrated1:25-1:1000.5 ml
BSB 2466Concentrated1:25-1:1001.0 ml
BSB 2467Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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