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CDK4 – RMab

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HC of CDK4 on a FFPE Colon Carcinoma Tissue

IHC of CDK4 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a).Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression.
Binh et al. reported a high expression of CDK4 (92%) in atypical lipomatous tumor/well-differentiated liposarcomas (ALT-WDLPS) and dedifferentiated liposarcomas (DDLPS). CDK4 is useful in differentiating ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
Antibody Type Rabbit Monoclonal Clone EP180
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Skin, Colon Carcinoma, Liposarcoma
Presentation CDK4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2461 Prediluted Ready-To-Use 3.0 ml
BSB 2462 Prediluted Ready-To-Use 7.0 ml
BSB 2463 Prediluted Ready-To-Use 15.0 ml
BSB 2464 Concentrated 1:25-1:100 0.1 ml
BSB 2465 Concentrated 1:25-1:100 0.5 ml
BSB 2466 Concentrated 1:25-1:100 1.0 ml
BSB 2467 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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