IHC of CD68 on an FFPE Tonsil Tissue
|For In Vitro Diagnostic Use.
|Summary and Explanation
|The CD68 antigen is a heavily glycosylated trans-membrane protein of 87-115 kDa which is specifically expressed by tissue macrophages, Langerhans cells and, at low levels, by dendritic cells. CD68 could play a role in phagocytic activities of tissuemacrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. CD68 may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas.However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results.
|Tonsil, Lymph Node
|CD68 is a mouse monoclonal antibody derived from cell culture supernatant that
is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing
BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.