CD68 – MMab

Hc Of Cd68 On An Ffpe Tonsil Tissue

IHC of CD68 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use.
Summary and ExplanationThe CD68 antigen is a heavily glycosylated trans-membrane protein of 87-115 kDa which is specifically expressed by tissue macrophages, Langerhans cells and, at low levels, by dendritic cells. CD68 could play a role in phagocytic activities of tissuemacrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.CD68 marks cells of monocyte/macrophage lineage. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. CD68 may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas.However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results.
Antibody TypeMouse MonoclonalCloneKP-1
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmic, MembranousControlTonsil, Lymph Node
PresentationCD68 is a mouse monoclonal antibody derived from cell culture supernatant that
is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing
BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2712PredilutedReady-To-Use3.0 ml
BSB 2713PredilutedReady-To-Use7.0 ml
BSB 2714PredilutedReady-To-Use15.0 ml
BSB 2715Concentrated1:250-1:10000.1 ml
BSB 2716Concentrated1:250-1:10000.5 ml
BSB 2717Concentrated1:250-1:10001.0 ml
BSB 2718Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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