IHC of CD21 on an FFPE Tonsil Tissue
| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | CD21, also known as CR2, complement component (3d/Epstein Barr virus) receptor 2, is an integral membrane glycoprotein of molecular weight 140 kDa, involved in the complement system. CD21 binds to C3d. B-cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. Complement component receptor-2 (CR2) is the membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. Anti-CD21 is useful in the identification of follicular dendritic cell matrixes found in normal lymph nodes and tonsillar tissue. This antibody also labels Follicular Dendritic Cell Tumor/Sarcomas. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | EP64 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Membranous | Control | Tonsil, Lymph Node, Spleen | |||||||||||||||||||||||||||||||||
| Presentation | CD21 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
| * The CD21 antibody, clone EP64, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409. | ||||||||||||||||||||||||||||||||||||
