Calponin – MMab

SKU: e6bc50ce6dab Categories: , , , ,


IHC of Calponin on an FFPE Leiomyoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationCalponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin’s inhibition of the smooth-muscle ATPase. Calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.
Antibody TypeMouse MonoclonalCloneBSB-20
IsotypeIgG1/KReactivityParaffin, Frozen
LocalizationCytoplasmicControlAppendix, Uterus, Breast Ducts, Leiomyoma, Prostate, Colon, Breast, Skin
PresentationAnti-Calponin (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 5120PredilutedReady-To-Use3.0 ml
BSB 5121PredilutedReady-To-Use7.0 ml
BSB 5122PredilutedReady-To-Use15.0 ml
BSB 5123Concentrated1:50-1:2000.1 ml
BSB 5124Concentrated1:50-1:2000.5 ml
BSB 5125Concentrated1:50-1:2001.0 ml
BSB 5126Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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