| Intended Use | For In Vitro Diagnostic Use | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | Adrenocorticotropic Hormone (ACTH or corticotropin) is a polypeptide hormone synthesized from POMC, (Pro-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to Corticotropin-releasing Hormone (CRH) released by the hypothalamus. It consists of 39 amino acids. ACTH is a useful marker in the classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs), as well as other tumors (e.g.,some Small-Cell Carcinomas present in lung tissue) causing Paraneoplastic Syndromes by secreting ACTH. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | BSB-25 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1/K | Reactivity | Paraffin, Frozen | |||||||||||||||||||||||||||||||||
| Localization | Cytoplasmic | Control | Normal Pituitary | |||||||||||||||||||||||||||||||||
| Presentation | ACTH is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
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