IHC of Thrombomodulin on an FFPE Mesothelioma Tissue
|For In Vitro Diagnostic Use
|Summary and Explanation
|Thrombomodulin, also known as CD141, is an endothelial-specific type 1 membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia.
Thrombomodulin was initially identified in endothelial cells, but is also found in extra-vascular sites, such as synctiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus, and skin. Thrombodulin is a useful marker for detecting angiosarcoma, and can also be used to distinguish between mesothelioma (positive) from lung adenocarcinoma (negative).
|Placenta, Liver, Kidney, Tonsil, Cervix, Mesothelioma, Bladder, Transitional Cell Carcinoma
|Thrombomodulin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.