SOX-10 – RMab

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Ihc Of Cytokeratin Sox-10 On An Ffpe Melanoma Tissue

IHC of SOX-10 on an FFPE Melanoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationTranscription factor SOX-10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes.
SOX-10 is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells which usually express S100 protein. In scar specimens, immature fibroblasts, epithelioid granulomas, and histiocytic proliferations can histopathologically mimic residual melanoma and even be positive for MiTF and S100. However, SOX-10 is less likely to be expressed by fibroblasts or histiocytes, especially compared to MiTF and S100. Anti-SOX-10 produces a nuclear stain that provides a clean signal that is much sharper and darker in staining quality when compared to the use of antibodies against MiTF and S100.
Antibody TypeRabbit MonoclonalCloneEP268
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlSkin, Melanoma, Schwanoma
PresentationSOX-10 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2580PredilutedReady-To-Use3.0 ml
BSB 2581PredilutedReady-To-Use7.0 ml
BSB 2582PredilutedReady-To-Use15.0 ml
BSB 2583Concentrated1:50-1:2000.1 ml
BSB 2584Concentrated1:50-1:2000.5 ml
BSB 2585Concentrated1:50-1:2001.0 ml
BSB 2586Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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