Smoothelin – MMab

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Ihc Of Smoothelin On An Ffpe Uterus Tissue

IHC of Smoothelin on an FFPE Uterus Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationSmoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin. To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma.
Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma such as in transurethral resection specimens of urinary bladder tumrors. Anti-Smoothelin can also be useful in differentiationg between benign (+) and malignant smooth muscle tumors (-).
Antibody TypeMouse MonoclonalCloneR4A
IsotypeIgG1ReactivityParaffin, Frozen
LocalizationCytoplasmicControlLeiomyoma, Bladder. Prostate, Myometrium, Fallopian Tube, Colon, Transitional Cell Carcinoma
PresentationSmoothelin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2189PredilutedReady-To-Use3.0 ml
BSB 2190PredilutedReady-To-Use7.0 ml
BSB 2191PredilutedReady-To-Use15.0 ml
BSB 2192Concentrated1:25-1:1000.1 ml
BSB 2193Concentrated1:25-1:1000.5 ml
BSB 2194Concentrated1:25-1:1001.0 ml
BSB 2195Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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