PU.1 – RMab

Ihc Of Pu.1 On An Ffpe Lymphoma Tissue

IHC of PU.1 on an FFPE Lymphoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationPU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation and regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B lymphocytes, with the exception of plasma cells.
PU.1 is expressed in germinal center B-cells and mantle B-cells. The antibody is positive in various lymphomas including B-Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Burkitt Lymphoma, Diffuse Large Cell Lymphoma, Diffuse Large B-cell Lymphoma, T-cell rich B-cell Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma. It has been demonstrated that a high level of expression of GC antigens (including PU.1) has a positive association with longer overall survival and progression free survival in the case of Follicular Lymphoma.
Antibody TypeRabbit MonoclonalCloneEP18
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlTonsil, Lymph Node
PresentationPU.1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2154PredilutedReady-To-Use3.0 ml
BSB 2155PredilutedReady-To-Use7.0 ml
BSB 2156PredilutedReady-To-Use15.0 ml
BSB 2157Concentrated1:50-1:2000.1 ml
BSB 2158Concentrated1:50-1:2000.5 ml
BSB 2159Concentrated1:50-1:2001.0 ml
BSB 2160Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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