PAX-8 – RMab

Ihc Of Pax-8 On An Ffpe Ovarian Carcinoma Tissue

IHC of PAX-8 on an FFPE Ovarian Carcinoma Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationPAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 experession in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities.
PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast.
Antibody TypeRabbit MonoclonalCloneZR-1
IsotypeIgGReactivityParaffin, Frozen
LocalizationNuclearControlOvary, Thyroid
PresentationPAX-8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 2098PredilutedReady-To-Use3.0 ml
BSB 2099PredilutedReady-To-Use7.0 ml
BSB 2100PredilutedReady-To-Use15.0 ml
BSB 2101Concentrated1:25-1:1000.1 ml
BSB 2102Concentrated1:25-1:1000.5 ml
BSB 2103Concentrated1:25-1:1001.0 ml
BSB 2104Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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