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Parathyroid (PTH) – MMab

SKU: baab355a7fde Categories: , , ,

IHC of Parathyroid Hormone on an FFPE Parathyroid Tissue

IHC of Parathyroid Hormone on an FFPE Parathyroid Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas Calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta). PTH half-life is approximately 4 minutes.
Anti-PTH antibody is also useful to distinguish parathyroid hyperplasia/neoplasms from thyroid and metastatic neoplasms. If the patient’s hypercalcemic status is not known, PTH immunohistochemistry is helpful, especially if clear cell parathyroid carcinomas are nonsecretory and there is no abnormality in mineral metabolism. The other instance in which anti-PTH antibodies are useful is in the consideration of parathyroid carcinomas located primarily in the anterior mediastinum. In this situation distinction from primary thymic metastatic carcinomas, non-Hodgkin’s lymphoma and germ cell tumors is necessary.
Antibody Type Mouse Monoclonal Clone BSB-24
Isotype IgG2b/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Parathyroid
Presentation PTH is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2084 Prediluted Ready-To-Use 3.0 ml
BSB 2085 Prediluted Ready-To-Use 7.0 ml
BSB 2086 Prediluted Ready-To-Use 15.0 ml
BSB 2087 Concentrated 1:250-1:1000 0.1 ml
BSB 2088 Concentrated 1:250-1:1000 0.5 ml
BSB 2089 Concentrated 1:250-1:1000 1.0 ml
BSB 2090 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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